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Amarin Reports Fourth Quarter and Full Year 2025 Financial Results

Strategic Initiatives and Refined Business Model Produced Financial and Operating Efficiencies Established Long-Term License and Supply Agreement to Commercialize VAZKEPA® Across Europe and Sustained U.S. Market Leadership for VASCEPA® Franchise Total of 45 Publications (Abstracts, Posters, Manuscripts) Furthering the Expansion of the VASCEPA® /VAZKEPA® (icosapent ethyl) Body of Knowledge Supported in 2025 DUBLIN, Ireland and BRIDGEWATER, N.J., Feb. 25, 2026 (GLOBE NEWSWIRE) — Amarin Corporation plc (NASDAQ: AMRN), a company committed to advancing the science of cardiovascular disease worldwide, today announced financial results for the fourth quarter and full year ended December 31, 2025. “Our performance in the fourth quarter and full year of 2025 confirmed both the initial impact and long-term potential of our strategic initiatives and re-imagined operating model,” said Aaron Berg, President and Chief Executive Officer of Amarin. “We have entered 2026 from an improved position of market, operational, and financial strength. We have maintained our U.S. leading market share for VASCEPA and are actively expanding our presence in Europe for VAZKEPA via our long-term partnership agreement with Recordati S.p.A., strengthening our now fully partnered international commercial strategy. We are a leaner organization, having made great progress in reducing costs and narrowing our losses, while continuing to invest in expanding an already formidable body of scientific knowledge that supports our global VASCEPA/VAZKEPA franchise and its proven ability to reduce cardiovascular risk. While work remains, we are encouraged by our progress and continue to examine strategic actions to maximize future shareholder value and options regarding management of capital.”            Q4 2025 Financial Highlights   ($ in millions)Q4 2025Q4 2024% ChangeTotal Net Revenue$49.2$62.3(21)%Operating Expenses$29.5$43.0(31)%Operating LossOperating Margin % *$(6.3)(13)%$(52.5)(84)%(88)%NMNet LossNet Margin$(1.2)(2)%$(48.6)(78)%(97)%NMCash$302.6$294.2  * Operating margin is calculated as operating loss divided by total net revenue. NM – Not Meaningful Peter Fishman, Amarin’s Chief Financial Officer, said, “Our fourth quarter performance reflects our early success in optimizing the Company’s operations and creating what we believe is a more efficient platform for long-term growth. We realized $31 million of the expected $70 million in cost savings from our restructuring initiatives and have incurred nearly all of the $37 – $40 million in restructuring costs. Our cash position improved sequentially and year over year, ending 2025 with total cash and investments of $303 million and no debt. As a direct result of our continued revenue generation and new financial operating profile, our return to positive cash flow in the fourth quarter was ahead of schedule and has positioned us to generate positive cash flow for the full year ahead. We are well positioned to deliver on our operational and strategic priorities in 2026.” Q4 2025 Financial PerformanceComparisons to Q4 2024, unless otherwise stated Revenues ($ in millions)Q4 2025Q4 2024% ChangeProduct Revenue, net:   U.S.   Europe   Rest-of-World (ROW)$41.1$2.3$3.1$44.2$4.0$11.9(7)%(42)%(74)%Total Product Revenue, net$46.5$60.1(23)%Licensing & Royalties$2.7$2.220%Total Net Revenue$49.2$62.3(21)%NM – Not Meaningful Total Net Revenue: Decreased $13.1 million, or 21%, due primarily to a decline in ROW sales that reflected a $7.8 million stocking order in last year’s fourth quarter in preparation for a market launch, a decline in net selling price in the U.S., and the effects of the transition of our European sales activities to Recordati that included both supply shipments and direct sales in the 2025 fourth quarter. European sales in the fourth quarter of 2024 included direct sales only; once the transition to a fully partnered sales model is complete, European sales will consist only of supply shipments to Recordati. Royalties increased by $0.5 million due to higher in-market sales generated by our global partners.     Operating ExpensesComparisons to Q4 2024, unless otherwise stated ($ in millions)Q4 2025Q4 2024% ChangeCOGS$26.1$71.9 SG&A$20.1$37.0 R&D$5.4$6.0 Restructuring$4.1–NMTotal Operating Expenses *$29.5$43.0  * Total operating expenses reflect the sum of SG&A, R&D, and Restructuring expenses.NM – Not Meaningful Total Operating Expenses: Decreased $13.5 million, or 31%, primarily due to the impact of the June 2025 Global Restructuring Plan that produced declines in Selling, General, and Administrative expenses (SG&A). Excluding the restructuring charge of $4.1 million (see discussion below), Q4 2025 total operating expenses were $25.4 million, representing a decline of 41%. COGS: Decreased $45.8 million, or 64%. COGS in Q4 2024 included a one-time inventory restructuring charge of $36.5 million related to the Company’s efforts to amend supplier agreements to align with then current and expected future demand and a one-time inventory write off. Excluding these one-time charges, Q4 2025 COGS decreased $2.8 million, or 10%, primarily due to lower net product sales. SG&A: Decreased $16.9 million, or 46%, primarily due to a reduction in costs pursuant to the Global Restructuring Plan and other cost optimization initiatives. R&D: Consistent with the prior year period. Restructuring: The Company recognized $4.1 million in Q4 2025 related to the continued implementation of the Global Restructuring Plan associated with the execution of the Recordati Licensing Agreement announced in June 2025. This resulted in the elimination of commercial roles in the Company’s Europe operations, among other operating expense savings across the Company’s global operations. The Company incurred $36.2 million of restructuring charges in full year 2025 and continues to expect total restructuring charges to range from $37 to $40 million, with the remaining charges expected to be realized in early 2026. Additional Q4 2025 Financial Information Comparisons to Q4 2024, unless otherwise stated Operating Loss: Narrowed to $6.3 million from an operating loss of $52.5 million, an improvement of $46.2 million, or 88%. Operating loss in Q4 2025 included restructuring costs of $4.1 million compared to $36.5 million in Q4 2024. Net Loss: Improved to $(1.2) million, or $(0.00) per share, from a net loss of $(48.6) million, or $(0.12) per share. Cash: Reported aggregate cash and investments of $302.6 million, as of December 31, 2025, compared to $294.2 million as of December 31, 2024, reflecting a year-over-year increase of $8.4 million, and compared to $286.6 million as of September 30, 2025, reflecting a sequential increase of $16.0 million. Debt: Remained debt free as of December 31, 2025. Fourth Quarter and Full Year 2025 Earnings Conference Call and Webcast InformationAmarin will host a conference call on February 25, 2026, at 8:00 a.m. ET to discuss this information. The conference call can be accessed on the investor relations section of the Company’s website at www.amarincorp.com, or via telephone by dialing 888-506-0062 within the United States, 973-528-0011 from outside the United States, and referencing conference ID 675507. A replay of the webcast will be made available until August 25,2026. To listen to a replay of the call, dial 877-481-4010 from within the United States and 919-882-2331 from outside of the United States, and reference conference ID 53567. A replay of the call will also be available through the Company’s website shortly after the call.  About Amarin Amarin is a global pharmaceutical company committed to reducing the cardiovascular disease (CVD) burden for patients and communities and to advancing the science of cardiovascular care around the world.  We own and support a global branded product approved by multiple regulatory authorities based on a track record of proven efficacy and safety and backed by robust clinical trial evidence.  Our commercialization model includes a direct sales approach in the U.S. and an indirect distribution strategy internationally, through a syndicate of reputable and well-established partners with significant geographic expertise, covering close to 100 markets worldwide. Our success is driven by a dedicated, talented, and highly skilled team of experts passionate about the fight against the world’s leading cause of death, CVD.     About VASCEPA®/VAZKEPA® (icosapent ethyl) CapsulesVASCEPA (icosapent ethyl) capsules are the first prescription treatment approved by the U.S. Food and Drug Administration (FDA) comprised solely of the active ingredient, icosapent ethyl (IPE), a unique form of eicosapentaenoic acid. VASCEPA was launched in the United States in January 2020 as the first drug approved by the U.S. FDA for treatment of the studied high-risk patients with persistent cardiovascular risk despite being on statin therapy. VASCEPA was initially launched in the United States in 2013 based on the drug’s initial FDA approved indication for use as an adjunct therapy to diet to reduce triglyceride levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia. Since launch, VASCEPA has been prescribed more than twenty-five million times. VASCEPA is covered by most major medical insurance plans. In addition to the United States, VASCEPA is approved and sold in Canada, China, Australia, Lebanon, the United Arab Emirates, Saudi Arabia, Qatar, Bahrain, and Kuwait. In Europe, in March 2021 marketing authorization was granted to icosapent ethyl in the European Union for the reduction of risk of cardiovascular events in patients at high cardiovascular risk, under the brand name VAZKEPA. In April 2021 marketing authorization for VAZKEPA (icosapent ethyl) was granted in the United Kingdom (applying to England, Scotland, Wales, and Northern Ireland).   VAZKEPA (icosapent ethyl) is currently approved and sold in Europe in Sweden, Finland, England/Wales, Spain, Netherlands, Scotland, Greece, Portugal, Italy, Denmark and Austria. United States Indications and Limitation of UseVASCEPA is indicated:   As an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization and unstable angina requiring hospitalization in adult patients with elevated triglyceride (TG) levels (≥ 150 mg/dL) and established cardiovascular disease or diabetes mellitus and two or more additional risk factors for cardiovascular disease.  As an adjunct to diet to reduce TG levels in adult patients with severe (≥ 500 mg/dL) hypertriglyceridemia.  The effect of VASCEPA on the risk for pancreatitis in patients with severe hypertriglyceridemia has not been determined.  Important Safety Information  VASCEPA is contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to VASCEPA or any of its components.VASCEPA was associated with an increased risk (3% vs 2%) of atrial fibrillation or atrial flutter requiring hospitalization in a double-blind, placebo-controlled trial. The incidence of atrial fibrillation was greater in patients with a previous history of atrial fibrillation or atrial flutter. It is not known whether patients with allergies to fish and/or shellfish are at an increased risk of an allergic reaction to VASCEPA. Patients with such allergies should discontinue VASCEPA if any reactions occur. VASCEPA was associated with an increased risk (12% vs 10%) of bleeding in a double-blind, placebo-controlled trial. The incidence of bleeding was greater in patients receiving concomitant antithrombotic medications, such as aspirin, clopidogrel or warfarin. Common adverse reactions in the cardiovascular outcomes trial (incidence ≥3% and ≥1% more frequent than placebo): musculoskeletal pain (4% vs 3%), peripheral edema (7% vs 5%), constipation (5% vs 4%), gout (4% vs 3%), and atrial fibrillation (5% vs 4%). Common adverse reactions in the hypertriglyceridemia trials (incidence >1% more frequent than placebo): arthralgia (2% vs 1%) and oropharyngeal pain (1% vs 0.3%). Adverse events may be reported by calling 1-855-VASCEPA or the FDA at 1-800-FDA-1088. Patients receiving VASCEPA and concomitant anticoagulants and/or anti-platelet agents should be monitored for bleeding. FULL U.S. FDA-APPROVED VASCEPA PRESCRIBING INFORMATION CAN BE FOUND AT WWW.VASCEPA.COM Europe For further information about the Summary of Product Characteristics (SmPC) for VAZKEPA® in Europe, please visit:  https://www.ema.europa.eu/en/documents/product-information/vazkepa-epar-product-information_en.pdf Globally, prescribing information varies; refer to the individual country product label for complete information. Use of Non-GAAP Adjusted Financial InformationIncluded in this press release are non-GAAP adjusted financial information as defined by U.S. Securities and Exchange Commission Regulation G. The GAAP financial measure is most directly comparable to each non-GAAP adjusted financial measure used or discussed, and a reconciliation of the differences between each non-GAAP adjusted financial measure and the comparable GAAP financial measure, is included in this press release after the condensed consolidated financial statements. Non-GAAP adjusted net (loss) income was derived by taking GAAP net loss and adjusting it for non-cash stock-based compensation expense, restructuring expense and other one-time expenses. Management uses these non-GAAP adjusted financial measures for internal reporting and forecasting purposes, when publicly providing its business outlook, to evaluate the company’s performance and to evaluate and compensate the company’s executives. The company has provided these non-GAAP financial measures in addition to GAAP financial results because it believes that these non-GAAP adjusted financial measures provide investors with a better understanding of the company’s historical results from its core business operations. While management believes that these non-GAAP adjusted financial measures provide useful supplemental information to investors regarding the underlying performance of the company’s business operations, investors are reminded to consider these non-GAAP measures in addition to, and not as a substitute for, financial performance measures prepared in accordance with GAAP. Non-GAAP measures have limitations in that they do not reflect all the amounts associated with the company’s results of operations as determined in accordance with GAAP. In addition, it should be noted that these non-GAAP financial measures may be different from non-GAAP measures used by other companies, and management may utilize other measures to illustrate performance in the future. Forward-Looking StatementsThis press release contains forward-looking statements which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including beliefs about Amarin’s key achievements in 2025 and the potential impact and outlook for achievements in 2026 and beyond; Amarin’s 2026 financial outlook and cash position; Amarin’s overall efforts to expand access and reimbursement to VAZKEPA across global markets; expectations regarding potential strategic collaboration and licensing agreements with third parties, including our ability to attract additional collaborators, as well as our plans and strategies for entering into potential strategic collaboration and licensing agreements and the overall potential and future success of VASCEPA/VAZKEPA and Amarin that are based on the beliefs and assumptions and information currently available to Amarin. All statements other than statements of historical fact contained in this press release are forward-looking statements. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin’s filings with the U.S. Securities and Exchange Commission. Amarin’s annual report on Form 10-K for the fiscal year ended 2025 will also be accessible there later this week. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date they are made. Amarin undertakes no obligation to update or revise the information contained in its forward-looking statements, whether as a result of new information, future events or circumstances or otherwise. Amarin’s forward-looking statements do not reflect the potential impact of significant transactions the company may enter into, such as mergers, acquisitions, dispositions, joint ventures or any material agreements that Amarin may enter into, amend or terminate. Investors and others should note that Amarin communicates with its investors and the public using the company website (www.amarincorp.com), the investor relations website (www.amarincorp.com/investor-relations), including but not limited to investor presentations and investor FAQs, U.S. Securities and Exchange Commission filings, press releases, public conference calls and webcasts. Amarin Contact InformationMedia Inquiries:Tegan BerryAmarin Corporation plcPR@amarincorp.com Investor Inquiries:Devin Sullivan & Conor RodriguezThe Equity Group on Behalf of Amarin devin.sullivan.ext@amarincorp.com or conor.rodriguez.ext@amarincorp.com Investor.relations@amarincorp.com -Tables to Follow-   CONSOLIDATED BALANCE SHEET DATA  (U.S. GAAP)  Unaudited *            December 31, 2025 December 31, 2024    (in thousands)  ASSETS       Current Assets:       Cash and cash equivalents  $134,660  $121,038   Restricted cash   201   300   Short-term investments  167,929   173,182   Accounts receivable, net   126,832   122,279   Inventory  195,910   166,048   Prepaid and other current assets   24,350   12,552   Total current assets   649,882   595,399   Property, plant and equipment, net   12   16   Long-term inventory  —   64,740   Operating lease right-of-use asset   6,461   7,592   Other long-term assets   1,055   1,213   Intangible asset, net   13,365   16,389   TOTAL ASSETS  $670,775  $685,349   LIABILITIES AND STOCKHOLDERS’ EQUITY       Current Liabilities:       Accounts payable  $45,355  $40,366   Accrued expenses and other current liabilities  149,104   139,583   Total current liabilities   194,459   179,949   Long-Term Liabilities:       Long-term operating lease liability  6,080   7,723   Other long-term liabilities   10,955   11,501   Total liabilities   211,494   199,173   Stockholders’ Equity:      Common stock   310,184   305,298   Additional paid-in capital   1,923,801   1,914,750   Treasury stock   (67,360)  (65,326)  Accumulated deficit   (1,707,344)  (1,668,546)  Total stockholders’ equity   459,281   486,176   TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY  $670,775  $685,349          * Unaudited as a standalone schedule; copied from consolidated financial statements          CONSOLIDATED STATEMENTS OF OPERATIONS DATA  (U.S. GAAP)  Unaudited *               Three Months Ended December 31, Year Ended December 31,    (in thousands, except per share amounts) (in thousands, except per share amounts)     2025   2024   2025   2024              Product revenue, net$46,543  $60,068  $182,753  $204,590   Licensing and royalty revenue 2,676   2,238   30,893   24,024   Total revenue, net 49,219   62,306   213,646   228,614   Less: Cost of goods sold 26,050   35,399   92,778   110,758   Less: Cost of goods sold – restructuring inventory —   36,474   —   36,474   Gross margin 23,169   (9,567)  120,868   81,382   Operating expenses:         Selling, general and administrative (1) 20,059   36,970   115,003   152,310   Research and development (1) 5,371   5,985   19,806   20,869   Restructuring 4,064   —   36,229   —   Total operating expenses 29,494   42,955   171,038   173,179   Operating loss (6,325)  (52,522)  (50,170)  (91,797)  Interest income 2,570   3,371   10,853   13,403   Interest expense (1)  (3)  (7)  (7)  Other income (expense), net 2,904   (753)  3,276   1,201   Loss from operations before taxes (852)  (49,907)  (36,048)  (77,200)  (Provision for) benefit from income taxes (372)  1,289   (2,750)  (4,983)  Net loss$(1,224) $(48,618) $(38,798) $(82,183)  Loss per share:         Basic$(0.00) $(0.12) $(0.09) $(0.20)  Diluted$(0.00) $(0.12) $(0.09) $(0.20)  Weighted average shares outstanding:         Basic 416,000   411,293   414,984   410,937   Diluted 416,000   411,293   414,984   410,937              * Unaudited as a standalone schedule; copied from consolidated financial statements  (1) Excluding non-cash stock-based compensation, selling, general and administrative expenses were $105,759 and $138,144 for the years ended December 31, 2025 and 2024, respectively, and research and development expenses were $17,345 and $17,330, respectively, for the same periods.                RECONCILIATION OF NON-GAAP NET (LOSS) INCOME  Unaudited                   Three months ended December 31, Year Ended December 31,    (in thousands, except per share amounts) (in thousands, except per share amounts)    2025  2024  2025  2024                  Net (loss) income for EPS – GAAP $(1,224)  $(48,618)  $(38,798)  $(82,183)   Stock-based compensation expense  1,559    3,400    11,705    17,705    Restructuring expense 4,064    —    36,229    —    Restructuring Inventory  —    36,474    —    36,474    ADS Ratio Change Fees  —    —    2,015    —    Licensing Agreement Fees  —    —    5,038    —   Adjusted net (loss) income for EPS – non-GAAP $4,399   $(8,744)  $16,189   $(28,004)                 Basic and diluted                            (Loss) earnings per share:             Basic – non-GAAP $0.01   $(0.02)  $0.04   $(0.07)  Diluted – non-GAAP $0.01   $(0.02)  $0.04   $(0.07)                 Weighted average shares:             Basic  416,000    411,293    414,984    410,937   Diluted  433,019    411,293    427,104    410,937                 

Merit Medical Reports Fourth Quarter and Full Year 2025 Results and Issues Fiscal Year 2026 Guidance

Fourth Quarter Highlights† Reported revenue of $393.9 million, up 11%Constant currency revenue* and constant currency revenue, organic* up 10% and up 7%, respectivelyGAAP operating margin of 13.8%, compared to 10.3% in prior year periodNon-GAAP operating margin* of 21.0%, compared to 19.6% in prior year periodGAAP EPS $0.63, up 37%Non-GAAP EPS* $1.04, up 12%Free cash flow* generation of $74.0 million, up 13% Fiscal Year 2025 Highlights† Reported revenue of $1.516 billion, up 12%Constant currency revenue* and constant currency revenue, organic* up 11% and up 7%, respectivelyGAAP operating margin of 12.2%, compared to 11.5% in prior yearNon-GAAP operating margin* of 20.3%, compared to 19.0% in prior yearGAAP EPS $2.13, up 5%Non-GAAP EPS* $3.83, up 11%Free cash flow* generation of $215.7 million, up 16% Fiscal Year 2026 Guidance Total revenue of $1.610 billion to $1.630 billion, up 6% – 8% year-over-year on a reported basis and up 5% – 7% year-over-year on a constant currency* basis.Non-GAAP EPS of $4.01 to $4.15, up 5% – 8% year-over-year. † Comparisons above are calculated for the current quarter compared with the fourth quarter of 2024 or for the current year compared with fiscal year 2024, as applicable, unless otherwise specified. Amounts stated in this release are rounded, while percentages are calculated from the underlying amounts. * Constant currency revenue; constant currency revenue, organic; non-GAAP gross profit and margin; non-GAAP operating income and margin; non-GAAP net income; non-GAAP EPS; and free cash flow figures (used here and below) are non-GAAP financial measures. A reconciliation of these financial measures to their most directly comparable GAAP financial measures is included under the heading “Non-GAAP Financial Measures” below. SOUTH JORDAN, Utah, Feb. 24, 2026 (GLOBE NEWSWIRE) — Merit Medical Systems, Inc. (NASDAQ: MMSI), a leading global manufacturer and marketer of healthcare technology, today announced financial results for the three and twelve-month periods ended December 31, 2025. “Merit delivered better-than-expected revenue and financial results in the fourth quarter,” said Martha G. Aronson, Merit’s President and CEO. “Our fourth quarter capped off an impressive year of operating and financial performance in 2025; we delivered 6.8% organic, constant currency revenue growth, a 130 basis-point improvement year-over-year in our non-GAAP operating margin and generated strong free cash flow of more than $215 million, a 16% increase year-over-year. We are introducing 2026 revenue and non-GAAP earnings per share guidance which reflects confidence in our team’s ability to deliver continued strong execution, stable constant currency growth, improving profitability and solid free cash flow generation again this year. Importantly, the team remains laser focused on delivering the final year of our Continued Growth Initiatives Program and the related financial targets for the three-year period ending December 31, 2026.” Merit’s revenue by operating segment and product category for the three and twelve-month periods ended December 31, 2025 and 2024 was as follows (unaudited; in thousands, except for percentages):                      Three Months Ended  Reported    Constant Currency*  December 31,    Impact of foreign December 31,     2025 2024(1) % Change exchange 2025 % ChangeCardiovascular                  Peripheral Intervention $154,933 $135,235 15 % $(1,635) $153,298 13 %Cardiac Intervention  117,240  95,228 23 %  (1,883)  115,357 21 %Custom Procedural Solutions  53,621  50,923 5 %  (562)  53,059 4 %OEM  48,085  56,314 (15)%  (300)  47,785 (15)%Total  373,879  337,700 11 %  (4,380)  369,499 9 %                   Endoscopy                  Endoscopy Devices  20,057  17,458 15 %  (15)  20,042 15 %                   Total $393,936 $355,158 11 % $(4,395) $389,541 10 %                      Year Ended  Reported    Constant Currency *  December 31,    Impact of foreign December 31,     2025 2024(1) % Change exchange 2025 % ChangeCardiovascular                  Peripheral Intervention $579,840 $532,770 9% $(1,191) $578,649 9%Cardiac Intervention  448,914  368,951 22%  (2,213)  446,701 21%Custom Procedural Solutions  209,333  200,033 5%  (1,228)  208,105 4%OEM  204,955  199,990 2%  (521)  204,434 2%Total  1,443,042  1,301,744 11%  (5,153)  1,437,889 10%                   Endoscopy                  Endoscopy Devices  72,864  54,770 33%  (20)  72,844 33%                   Total $1,515,906 $1,356,514 12% $(5,173) $1,510,733 11%                     (1)   Commencing January 1, 2025, Merit reorganized its sales teams and product categories to include revenues from the sale of its spine devices under its OEM product category. Revenue figures for 2024 have been recast to reflect this realignment of its portfolio of spine products, representing approximately $5.9 million and $22.6 million in revenue for the three and twelve-month periods ended December 31, 2024, respectively, within the OEM product category to provide comparability between the reporting periods. Fourth Quarter 2025 Financial Summary: GAAP gross margin was 49.6%, compared to 48.7% for the fourth quarter of 2024. Non-GAAP gross margin* was 54.5%, compared to 53.5% for the fourth quarter of 2024. GAAP operating margin was 13.8%, compared to 10.3% for the fourth quarter of 2024. Non-GAAP operating margin* was 21.0%, compared to 19.6% for the fourth quarter of 2024. GAAP net income was $38.0 million, or $0.63 per share, compared to $27.9 million, or $0.46 per share, for the fourth quarter of 2024. Non-GAAP net income* was $62.5 million, or $1.04 per share, compared to $56.3 million, or $0.93 per share, for the fourth quarter of 2024. Fiscal Year 2025 Financial Summary: GAAP gross margin was 48.7%, compared to 47.4% for fiscal year 2024. Non-GAAP gross margin* was 53.7%, compared to 51.7% for fiscal year 2024. GAAP operating margin was 12.2%, compared to 11.5% for fiscal year 2024. Non-GAAP operating margin* was 20.3%, compared to 19.0% for fiscal year 2024. GAAP net income was $128.5 million, or $2.13 per share, compared to $120.4 million, or $2.03 per share, for fiscal year 2024. Non-GAAP net income* was $231.4 million, or $3.83 per share, compared to $205.4 million, or $3.46 per share, for fiscal year 2024. As of December 31, 2025, Merit had cash and cash equivalents of $446.4 million and total debt obligations of $747.5 million, compared to cash and cash equivalents of $376.7 million and total debt obligations of $747.5 million as of December 31, 2024. Merit had available borrowing capacity of approximately $697 million as of December 31, 2025. Fiscal Year 2026 Financial Guidance Based upon the information currently available to Merit’s management, for the twelve-months ending December 31, 2026, absent the potential impact of trade policies and related actions implemented by the U.S. and other countries subsequent to today’s date, material acquisitions, non-recurring transactions or other factors beyond Merit’s current expectations, Merit anticipates the following financial results: Revenue and Earnings Guidance*        Year EndedYear Ending% ChangeFinancial Measure December 31, 2025December 31, 2026Y/YTotal Revenue $1.516 billion$1.610 – $1.630 billion6% – 8%     Non-GAAP Earnings Per Share(1) $3.83$4.01 – $4.155% – 8%      *Percentage figures approximated; dollar figures may not foot due to rounding.(1) Merit’s non-GAAP earnings per share reflect the dilutive impact of its 3.00% Convertible Senior Notes due 2029 (the “Convertible Notes”) calculated using the if-converted method of approximately $0.07 per share for the year ending December 31, 2026. Any offsetting impacts of the capped call associated with the Convertible Notes are not considered. Merit does not provide guidance for GAAP reported financial measures (other than revenue) or a reconciliation of forward-looking non-GAAP financial measures to the most directly comparable GAAP reported financial measures (other than revenue) because Merit is unable to predict with reasonable certainty the financial impact of various items which could impact Merit’s future financial results, such as expenses attributable to acquisitions or other extraordinary transactions, non-cash expenses related to amortization or write-off of previously acquired tangible and intangible assets, certain employee termination benefits, performance-based stock compensation expenses, expenses resulting from non-ordinary course litigation or administrative proceedings and resulting settlements, governmental proceedings, and changes in governmental or industry regulations. These items are uncertain, depend on various factors, and could have a material impact on GAAP reported results for the guidance period. For the same reasons, Merit is unable to address the significance of the unavailable information, which could be material to future results. Specifically, Merit is not, without unreasonable effort, able to reliably predict the impact of these items and Merit believes inclusion of a reconciliation of these forward-looking non-GAAP measures to their GAAP counterparts could be confusing to investors or cause undue reliance. Merit’s financial guidance for the year ending December 31, 2026 is subject to risks and uncertainties identified in this release and Merit’s filings with the U.S. Securities and Exchange Commission (the “SEC”). This guidance is based on information and estimates available to Merit as of February 24, 2026. Should known or unknown risks or uncertainties materialize or should underlying assumptions prove inaccurate, actual results will likely vary, and could vary materially, from past results and those anticipated, estimated or projected. CONFERENCE CALL As previously announced, Merit will hold its investor conference call today, Tuesday, February 24, 2026, at 4:30 p.m., Eastern Time, to discuss its results for the fourth quarter and year ended December 31, 2025 and provide an operational update. To access the conference call, please pre-register using the following link. Registrants will receive confirmation with dial-in details. A live webcast and slide deck will also be available at merit.com. CONSOLIDATED BALANCE SHEETS(in thousands)         December 31,     2025 December 31,  (Unaudited) 2024ASSETS      Current Assets      Cash and cash equivalents $446,404  $376,715 Trade receivables, net  203,710   190,243 Other receivables  17,773   16,588 Inventories  333,705   306,063 Prepaid expenses and other assets  31,493   28,544 Prepaid income taxes  4,941   3,286 Income tax refund receivables  2,128   2,335 Total current assets  1,040,154   923,774        Property and equipment, net  428,401   386,165 Intangible assets, net  537,654   498,265 Goodwill  506,837   463,511 Deferred income tax assets  7,049   16,044 Operating lease right-of-use assets  87,600   65,508 Other assets  78,227   65,336 Total Assets $2,685,922  $2,418,603        LIABILITIES AND STOCKHOLDERS’ EQUITY      Current Liabilities      Trade payables $60,551  $68,502 Accrued expenses  159,486   134,077 Current operating lease liabilities  10,876   10,331 Income taxes payable  8,851   3,492 Total current liabilities  239,764   216,402        Long-term debt  734,038   729,551 Deferred income tax liabilities  19,665   240 Liabilities related to unrecognized tax benefits  2,248   2,118 Deferred compensation payable  17,542   19,197 Deferred credits  1,398   1,502 Long-term operating lease liabilities  76,658   54,783 Other long-term obligations  10,306   15,451 Total liabilities  1,101,619   1,039,244        Stockholders’ Equity      Common stock  763,909   703,219 Retained earnings  824,030   695,541 Accumulated other comprehensive loss  (3,636)  (19,401)Total stockholders’ equity  1,584,303   1,379,359 Total Liabilities and Stockholders’ Equity $2,685,922  $2,418,603  CONSOLIDATED STATEMENTS OF INCOME(Unaudited, in thousands except per share amounts)               Three Months Ended Year Ended  December 31, December 31,  2025  2024  2025  2024 Net sales $393,936  $355,158  $1,515,906  $1,356,514 Cost of sales  198,584   182,175   777,636   713,181 Gross profit  195,352   172,983   738,270   643,333              Operating expenses:            Selling, general and administrative  114,830   111,074   455,214   399,731 Research and development  26,541   25,194   97,352   87,466 Contingent consideration (benefit) expense  (214)  151   984   443 Total operating expenses  141,157   136,419   553,550   487,640              Income from operations  54,195   36,564   184,720   155,693              Other income (expense):            Interest income  3,904   4,741   15,070   26,230 Interest expense  (6,364)  (7,993)  (26,461)  (31,219)Other expense — net  (675)  (167)  (2,392)  (711)Total other expense — net  (3,135)  (3,419)  (13,783)  (5,700)             Income before income taxes  51,060   33,145   170,937   149,993              Income tax expense  13,054   5,198   42,448   29,636              Net income $38,006  $27,947  $128,489  $120,357              Earnings per common share            Basic $0.64  $0.48  $2.17  $2.07 Diluted $0.63  $0.46  $2.13  $2.03              Weighted average shares outstanding            Basic  59,343   58,541   59,158   58,218 Diluted  60,026   60,613   60,460   59,365  CONSOLIDATED STATEMENTS OF CASH FLOWS(Unaudited, in thousands)         Year Ended  December 31,  2025  2024 CASH FLOWS FROM OPERATING ACTIVITIES:    Net income $128,489  $120,357 Adjustments to reconcile net income to net cash provided by operating activities:      Depreciation and amortization  123,168   102,709 Gain on disposition of a business  (249)  — Write-off of certain intangible assets and other long-term assets  313   456 Amortization of right-of-use operating lease assets  11,481   12,023 Fair value adjustments related to contingent consideration liabilities  984   443 Deferred income taxes  5,214   (14,873)Stock-based compensation expense  43,460   28,473 Other adjustments  7,855   8,156 Changes in operating assets and liabilities, net of acquisitions  (23,344)  (36,945)Total adjustments  168,882   100,442 Net cash, cash equivalents, and restricted cash provided by operating activities  297,371   220,799        CASH FLOWS FROM INVESTING ACTIVITIES:      Capital expenditures for property and equipment  (81,716)  (35,140)Cash paid for notes receivable and other investments  (18,084)  (10,433)Cash paid in acquisitions, net of cash acquired  (144,769)  (320,182)Other investing, net  (2,817)  (2,898)Net cash, cash equivalents, and restricted cash used in investing activities  (247,386)  (368,653)       CASH FLOWS FROM FINANCING ACTIVITIES:    Proceeds from issuance of common stock  28,213   40,908 Proceeds from (payments on) long-term debt  —   (99,063)Contingent payments related to acquisitions  (2,685)  (261)Payment of taxes related to an exchange of common stock  (9,529)  (1,592)Net cash, cash equivalents, and restricted cash provided by (used in) financing activities  15,999   (60,008)Effect of exchange rates on cash  3,798   (2,515)Net increase (decrease) in cash, cash equivalents and restricted cash  69,782   (210,377)       CASH, CASH EQUIVALENTS AND RESTRICTED CASH:      Beginning of period  378,767   589,144 End of period $448,549  $378,767        RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH TO THE CONSOLIDATED BALANCE SHEETS:      Cash and cash equivalents  446,404   376,715 Restricted cash reported in prepaid expenses and other current assets  2,145   2,052 Total cash, cash equivalents and restricted cash $448,549  $378,767           Non-GAAP Financial Measures Although Merit’s financial statements are prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”), Merit’s management believes that the non-GAAP financial measures referenced in this release may provide investors with useful information regarding the underlying business trends and performance of Merit’s ongoing operations and can be useful for period-over-period comparisons of such operations. Non-GAAP financial measures used in this release include: constant currency revenue;constant currency revenue, organic;non-GAAP gross profit and margin;non-GAAP operating income and margin;non-GAAP net income;non-GAAP earnings per share; andfree cash flow. Merit’s management team uses these non-GAAP financial measures to evaluate Merit’s profitability and efficiency, to compare operating and financial results to prior periods, to evaluate changes in the results of its operating segments, and to measure and allocate financial resources internally. However, Merit’s management does not consider such non-GAAP measures in isolation or as an alternative to measures determined in accordance with GAAP. Readers should consider non-GAAP measures used in this release in addition to, not as a substitute for, financial reporting measures prepared in accordance with GAAP. These non-GAAP financial measures generally exclude some, but not all, items that may affect Merit’s net income. In addition, they are subject to inherent limitations as they reflect the exercise of judgment by management about which items are excluded. Merit believes it is useful to exclude such items in the calculation of non-GAAP gross profit and margin, non-GAAP operating income and margin, non-GAAP net income, and non-GAAP earnings per share (in each case, as further illustrated in the reconciliation tables below) because such amounts in any specific period may not directly correlate to the underlying performance of Merit’s business operations and can vary significantly between periods as a result of factors such as acquisition or other extraordinary transactions, non-cash expenses related to amortization or write-off of previously acquired tangible and intangible assets, certain employee termination benefits, expenses resulting from non-ordinary course litigation or administrative proceedings and resulting settlements, governmental proceedings or changes in tax or industry regulations, gains or losses on disposal of certain assets, equity method investment loss (income) from equity investees, and debt issuance costs. Merit may incur similar types of expenses in the future, and the non-GAAP financial information included in this release should not be viewed as a statement or indication that these types of expenses will not recur. Additionally, the non-GAAP financial measures used in this release may not be comparable with similarly titled measures of other companies. Merit urges readers to review the reconciliations of its non-GAAP financial measures to their most directly comparable GAAP financial measures included herein, and not to rely on any single financial measure to evaluate Merit’s business or results of operations. Constant Currency Revenue Merit’s constant currency revenue is prepared by converting the current-period reported revenue of subsidiaries whose functional currency is a currency other than the U.S. dollar at the applicable foreign exchange rates in effect during the comparable prior-year period and adjusting for the effects of hedging transactions on reported revenue, which are recorded in the U.S. dollar. The constant currency revenue adjustments of $(4.4) million and $(5.2) million to reported revenue for the three and twelve-month periods ended December 31, 2025, respectively, were calculated using the applicable average foreign exchange rates for the three and twelve-month periods ended December 31, 2024. Constant Currency Revenue, Organic Merit’s constant currency revenue, organic, is defined, with respect to prior fiscal year periods, as GAAP revenue. With respect to current fiscal year periods, constant currency revenue, organic, is defined as constant currency revenue (as defined above), less revenue from certain acquisitions. For the three-month period ended December 31, 2025, Merit’s constant currency revenue, organic, excludes revenues attributable to products acquired in connection with (i) the assets acquired from Pentax of America, Inc. related to the C2 CryoBalloon™ device in November 2025 (the “C2 Acquisition”), (ii) Merit’s merger transaction with Biolife Delaware, L.L.C. (“Biolife”) in May 2025 (the “Biolife Merger”) and (iii) the assets acquired from Cook Medical Holdings LLC in November 2024 (the “Cook Transaction”). For the twelve-month period ended December 31, 2025, Merit’s constant currency revenue, organic, excludes revenues attributable to products acquired in connection with (i) the C2 Acquisition, (ii) the Biolife Merger, (iii) the Cook Transaction and (iv) the assets acquired from EndoGastric Solutions, Inc. in July 2024 (the “EGS Transaction”). Non-GAAP Gross Profit and Margin Non-GAAP gross profit is calculated by reducing GAAP cost of sales by amounts recorded for amortization of intangible assets and inventory mark-up related to acquisitions. Non-GAAP gross margin is calculated by dividing non-GAAP gross profit by reported net sales. Non-GAAP Operating Income and Margin Non-GAAP operating income is calculated by adjusting GAAP operating income for certain items which are deemed by Merit’s management to be outside of core operations and vary in amount and frequency among periods, such as expenses related to acquisitions or other extraordinary transactions, non-cash expenses related to amortization or write-off of previously acquired tangible and intangible assets, certain employee termination benefits, performance-based stock compensation expenses, expenses resulting from non-ordinary course litigation or administrative proceedings and resulting settlements, governmental proceedings, and changes in governmental or industry regulations, as well as other items referenced in the tables below. Non-GAAP operating margin is calculated by dividing non-GAAP operating income by reported net sales. Non-GAAP Net Income Non-GAAP net income is calculated by adjusting GAAP net income for the items set forth in the definition of non-GAAP operating income above, as well as for expenses related to debt issuance costs, gains or losses on disposal of certain assets, equity method investment loss (income) from equity investees, and other items set forth in the tables below. Non-GAAP EPS Non-GAAP EPS is defined as non-GAAP net income divided by the diluted shares outstanding for the corresponding period. Free Cash Flow Free cash flow is defined as cash flow from operations calculated in accordance with GAAP, less capital expenditures for property and equipment calculated in accordance with GAAP, as set forth in the consolidated statement of cash flows. Other Non-GAAP Financial Measure Reconciliations The following tables set forth supplemental financial data and corresponding reconciliations of non-GAAP financial measures to Merit’s corresponding financial measures prepared in accordance with GAAP, in each case, for the three and twelve-month periods ended December 31, 2025 and 2024. The non-GAAP income adjustments referenced in the following tables do not reflect non-performance-based stock compensation expense of $4.4 million and $3.7 million for the three-month periods ended December 31, 2025 and 2024, respectively, and $18.2 million and $13.2 million for the twelve-month periods ended December 31, 2025 and 2024, respectively. Reconciliation of GAAP Net Income to Non-GAAP Net Income(Unaudited, in thousands except per share amounts)                Three Months Ended  December 31, 2025  Pre-Tax Tax Impact After-Tax Per Share ImpactGAAP net income $51,060  $(13,054) $38,006  $0.63              Non-GAAP adjustments:            Cost of Sales            Amortization of intangibles  19,237   (4,541)  14,696   0.24 Inventory mark-up related to acquisitions  97   (23)  74   0.00 Operating Expenses            Contingent consideration benefit  (214)  (3)  (217)  (0.00)Amortization of intangibles  2,586   (611)  1,975   0.03 Performance-based share-based compensation (a)  5,543   155   5,698   0.09 Corporate restructuring (b)  (346)  82   (264)  (0.00)Acquisition-related  602   (174)  428   0.01 Medical Device Regulation expenses (c)  929   (219)  710   0.01 Other (d)  50   (12)  38   0.00 Other (Income) Expense            Amortization of long-term debt issuance costs  1,414   (334)  1,080   0.02 Other non-operating loss (e)  415   (98)  317   0.01              Non-GAAP net income $81,373  $(18,832) $62,541  $1.04              Diluted shares           60,026                 Three Months Ended  December 31, 2024  Pre-Tax Tax Impact After-Tax Per Share ImpactGAAP net income $33,145 $(5,198) $27,947 $0.46             Non-GAAP adjustments:            Cost of Sales            Amortization of intangibles  16,832  (3,978)  12,854  0.21Inventory mark-up related to acquisitions  75  (17)  58  0.00Operating Expenses            Contingent consideration expense  151  48   199  0.00Amortization of intangibles  2,385  (564)  1,821  0.03Performance-based share-based compensation (a)  5,841  (141)  5,700  0.09Corporate restructuring (b)  1,098  (260)  838  0.01Acquisition-related  5,239  (1,237)  4,002  0.07Medical Device Regulation expenses (c)  1,395  (329)  1,066  0.02Other (d)  71  (16)  55  0.00Other (Income) Expense            Amortization of long-term debt issuance costs  2,338  (552)  1,786  0.03             Non-GAAP net income $68,570 $(12,244) $56,326 $0.93             Diluted shares           60,613              Note: Certain per-share impacts may not sum to totals due to rounding. Reconciliation of GAAP Net Income to Non-GAAP Net Income(Unaudited, in thousands except per share amounts)                Year Ended  December 31, 2025  Pre-Tax Tax Impact After-Tax Per Share ImpactGAAP net income $170,937 $(42,448) $128,489 $2.13             Non-GAAP adjustments:            Cost of Sales            Amortization of intangibles  75,035  (17,725)  57,310  0.95Inventory mark-up related to acquisitions  347  (82)  265  0.00Operating Expenses            Contingent consideration expense  984  26   1,010  0.02Amortization of intangibles  10,083  (2,382)  7,701  0.13Performance-based share-based compensation (a)  25,224  (2,189)  23,035  0.38Corporate restructuring (b)  2,527  (596)  1,931  0.03Acquisition-related  2,690  (176)  2,514  0.04Medical Device Regulation expenses (c)  5,812  (1,372)  4,440  0.07Other (d)  153  (36)  117  0.00Other (Income) Expense            Amortization of long-term debt issuance costs  5,656  (1,336)  4,320  0.07Other non-operating loss (e)  426  (159)  267  0.00             Non-GAAP net income $299,874 $(68,475) $231,399 $3.83             Diluted shares           60,460                Year Ended  December 31, 2024  Pre-Tax Tax Impact After-Tax Per Share ImpactGAAP net income $149,993 $(29,636) $120,357 $2.03             Non-GAAP adjustments:            Cost of Sales            Amortization of intangibles  57,659  (13,632)  44,027  0.74Inventory mark-up related to acquisitions  634  (149)  485  0.01Operating Expenses            Contingent consideration expense  443  17   460  0.01Amortization of intangibles  7,931  (1,876)  6,055  0.10Performance-based share-based compensation (a)  15,237  (1,607)  13,630  0.23Corporate restructuring (b)  3,128  (739)  2,389  0.04Acquisition-related  8,849  (2,089)  6,760  0.11Medical Device Regulation expenses (c)  7,515  (1,774)  5,741  0.10Other (d)  373  (88)  285  0.00Other (Income) Expense            Amortization of long-term debt issuance costs  6,769  (1,598)  5,171  0.09             Non-GAAP net income $258,531 $(53,171) $205,360 $3.46             Diluted shares           59,365              Note: Certain per-share impacts may not sum to totals due to rounding. Reconciliation of Reported Operating Income to Non-GAAP Operating Income (Unaudited, in thousands except percentages)                            Three Months Ended Three Months Ended Year Ended Year Ended  December 31, 2025 December 31, 2024 December 31, 2025 December 31, 2024  Amounts % Sales Amounts % Sales Amounts % Sales Amounts % SalesNet Sales as Reported $393,936     $355,158    $1,515,906    $1,356,514                            GAAP Operating Income  54,195  13.8 %  36,564 10.3%  184,720 12.2%  155,693 11.5%Cost of Sales                        Amortization of intangibles  19,237  4.9 %  16,832 4.7%  75,035 4.9%  57,659 4.3%Inventory mark-up related to acquisitions  97  0.0 %  75 0.0%  347 0.0%  634 0.0%Operating Expenses                        Contingent consideration (benefit) expense  (214) (0.1)%  151 0.0%  984 0.1%  443 0.0%Amortization of intangibles  2,586  0.7 %  2,385 0.7%  10,083 0.7%  7,931 0.6%Performance-based share-based compensation (a)  5,543  1.4 %  5,841 1.6%  25,224 1.7%  15,237 1.1%Corporate restructuring (b)  (346) (0.1)%  1,098 0.3%  2,527 0.2%  3,128 0.2%Acquisition-related  602  0.2 %  5,239 1.5%  2,690 0.2%  8,849 0.7%Medical Device Regulation expenses (c)  929  0.2 %  1,395 0.4%  5,812 0.4%  7,515 0.6%Other (d)  50  0.0 %  71 0.0%  153 0.0%  373 0.0%                         Non-GAAP Operating Income $82,679  21.0 % $69,651 19.6% $307,575 20.3% $257,462 19.0%                            Note: Certain percentages may not sum to totals due to rounding.       (a)   Represents performance-based share-based compensation expense, including stock-settled and cash-settled awards.       (b)   Includes employee termination benefits associated with activities related to corporate restructuring initiatives and costs to terminate certain distribution contracts from the Biolife Merger.       (c)   Represents incremental expenses incurred to comply with the E.U. Medical Device Regulation.       (d)   Represents costs to comply with Merit’s corporate integrity agreement with the U.S. Department of Justice.       (e)   Includes gains and losses associated with the disposal of business units and equity method investment loss (income) from equity investees. Reconciliation of Reported Revenue to Constant Currency Revenue (Non-GAAP), and Constant Currency Revenue, Organic (Non-GAAP)(Unaudited, in thousands except percentages)                      Three Months Ended   Year Ended    December 31,   December 31,  % Change 2025  2024 % Change 2025  2024Reported Revenue 10.9%$393,936  $355,158 11.8%$1,515,906  $1,356,514                 Add: Impact of foreign exchange    (4,395)  —    (5,173)  —                 Constant Currency Revenue (a) 9.7%$389,541  $355,158 11.4%$1,510,733  $1,356,514                 Less: Revenue from certain acquisitions    (10,840)  —    (62,285)  —                 Constant Currency Revenue, Organic (a) 6.6%$378,701  $355,158 6.8%$1,448,448  $1,356,514                          (a)   A non-GAAP financial measure. For a definition of this and other non-GAAP financial measures, see the section of this release entitled “Non-GAAP Financial Measures.” Reconciliation of Reported Gross Margin to Non-GAAP Gross Margin (Non-GAAP)(Unaudited, as a percentage of reported revenue)                Three Months Ended Year Ended  December 31, December 31,  2025  2024  2025  2024 Reported Gross Margin 49.6% 48.7% 48.7% 47.4%             Add back impact of:            Amortization of intangibles 4.9% 4.7% 4.9% 4.3%Inventory mark-up related to acquisitions 0.0% 0.0% 0.0% 0.0%             Non-GAAP Gross Margin 54.5% 53.5% 53.7% 51.7%              Note: Certain percentages may not sum to totals due to rounding. Reconciliation of Reported Cash Flow from Operations to Free Cash Flow (Non-GAAP) (Unaudited, in thousands)                Three Months Ended Year Ended  December 31, December 31,  2025  2024  2025  2024 Reported Cash Flow from Operations $98,510  $68,745  $297,371  $220,799              Less: Capital Expenditures  (24,464)  (3,472)  (81,716)  (35,140)             Free Cash Flow $74,046  $65,273  $215,655  $185,659                   Reconciliation of 2026 Net Sales Guidance – % Change from Prior Year (Constant Currency)        Low High2026 Net Sales Guidance – % Change from Prior Year (GAAP) 6.2% 7.5%Estimated impact of foreign currency exchange rate fluctuations (0.8%) (0.8%)2026 Net Sales Guidance – % Change from Prior Year (Constant Currency) 5.4% 6.7%      Note: Certain percentages may not sum to totals due to rounding. ABOUT MERIT Founded in 1987, Merit is engaged in the development, manufacture, and distribution of proprietary medical devices used in interventional, diagnostic, and therapeutic procedures, particularly in cardiology, radiology, oncology, critical care, and endoscopy. Merit serves customers worldwide with a domestic and international sales force and clinical support team totaling more than 800 individuals. Merit employs approximately 7,500 people worldwide. CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements include, among others: statements preceded or followed by, or that include the words, “may,” “will,” “should,” “expects,” “plans,” “anticipates,” “intends,” “seeks,” “believes,” “estimates,” “projects,” “forecasts,” “potential,” “target,” “continue,” “upcoming,” “optimistic” or other forms of these words or similar words or expressions, or the negative thereof or other comparable terminology;statements that address Merit’s future operating performance or events or developments that Merit’s management expects or anticipates will occur, including, without limitation, any statements regarding Merit’s projected revenues, earnings or other financial measures, Merit’s plans and objectives for future operations, Merit’s proposed new products or services, the integration, development or commercialization of the business or any assets acquired from other parties, future economic conditions or performance, the implementation of, and results which may be achieved through, Merit’s Continued Growth Initiatives Program or other business optimization initiatives, and any statements of assumptions underlying any of the foregoing; andstatements regarding Merit’s past performance, efforts, or results about which inferences or assumptions may be made, including statements proceeded or followed by the words “preliminary,” “initial,” “potential,” “possible,” “diligence,” “industry-leading,” “compliant,” “indications” or “early feedback” or other forms of these words or similar words or expressions, or the negative thereof or other comparable terminology. The forward-looking statements contained in this release are based on Merit management’s current expectations and assumptions regarding future events or outcomes. If underlying expectations or assumptions prove inaccurate, or risks or uncertainties materialize, actual results will likely differ, and may differ materially, from Merit’s expectations reflected in any forward-looking statements. Financial estimates are subject to change and are not intended to be relied upon as predictions of future operating results. Investors are cautioned not to unduly rely on any such forward-looking statements. The following are some of the important risks and uncertainties that could cause Merit’s actual results to differ from management’s expectations in any forward-looking statements: risks and uncertainties associated with Merit’s executive succession planning activities and leadership transition; risks and uncertainties regarding trade policies or related actions implemented by the U.S. or other countries, including existing, proposed, prospective or invalidated tariffs, duties or other measures; risks and uncertainties associated with Merit’s integration of businesses or products acquired from third parties, including the acquisitions of the businesses and products in connection with the C2 Acquisition and the Biolife Merger in 2025 and the Cook Transaction and the EGS Transaction in 2024, and Merit’s ability to achieve the anticipated financial results, product development and other anticipated benefits of such acquisitions; effects of Merit’s 3.00% Senior Convertible Notes on Merit’s net income and earnings per share performance; disruptions in Merit’s supply chain, manufacturing or sterilization processes; U.S. and global political, economic, competitive, reimbursement and regulatory conditions; modification or limitation of, or policies and procedures associated with, governmental or private insurance reimbursement policies; reduced availability of, and price increases associated with, components and other raw materials; increases in transportation expenses; risks relating to Merit’s potential inability to successfully manage growth through acquisitions generally, including the inability to effectively integrate acquired operations or products or commercialize technology developed internally or acquired through completed, proposed or future transactions; fluctuations in interest or foreign currency exchange rates and inflation; cybersecurity events; government scrutiny and regulation of the medical device industry; difficulties relating to development, testing and regulatory approval, clearance and maintenance of Merit’s products; the safety, efficacy and patient and physician adoption of Merit’s products; the ability to fully enroll and the outcomes of ongoing and future clinical trials and market studies relating to Merit’s products; litigation and other legal proceedings affecting Merit; failure to comply with U.S. and foreign laws and regulations; restrictions on Merit’s liquidity or business operations resulting from its debt agreements; infringement of Merit’s technology or the assertion that Merit’s technology infringes the rights of other parties; product recalls and product liability claims; potential for significant adverse changes in governing regulations; Merit’s divestiture of its DualCap® anti-microbial cap product line in February 2026, changes in tax laws and regulations in the United States or other jurisdictions or exposure to additional tax liabilities which may adversely affect Merit’s effective tax rate; termination of relationships with Merit’s suppliers, or failure of such suppliers to perform; development of new products and technology that could render Merit’s existing or future products obsolete; market acceptance of new products; failure to comply with applicable environmental laws; changes in key personnel; labor shortages and increases in labor costs; price and product competition; extreme weather events; and geopolitical events. For a further discussion of the risks and uncertainties which may affect Merit’s business, operations and financial condition, see Part I, Item 1A. “Risk Factors” in Merit’s Annual Report on Form 10-K for the year ended December 31, 2025 filed with the SEC. All subsequent forward-looking statements attributable to Merit or persons acting on its behalf are expressly qualified in their entirety by these cautionary statements. Actual results will likely differ, and may differ materially, from anticipated results. Financial estimates are subject to change and are not intended to be relied upon as predictions of future operating results. Those estimates and all other forward-looking statements included in this release are made only as of the date of this release, and except as otherwise required by applicable law, Merit assumes no obligation to update or disclose revisions to estimates and all other forward-looking statements. TRADEMARKS Unless noted otherwise, trademarks and registered trademarks used in this release are the property of Merit Medical Systems, Inc., its subsidiaries, or its licensors.      Contacts:   PR/Media Inquiries:Sarah ComstockMerit MedicalInvestor Inquiries:Mike Piccinino, CFA, IRCICR Healthcare  +1-801-432-2864+1-443-213-0509  sarah.comstock@merit.commike.piccinino@icrhealthcare.com     

BridgeBio Reports Fourth Quarter and Full Year 2025 Financial Results and Commercial Updates

$154.2 million in total fourth quarter revenues, net, and $502.1 million in full year revenues, net, primarily comprised of net product revenue of $146.0 million and $362.4 million, respectivelyBridgeBio reported three positive Phase 3 trial readouts in just over three months, a demonstration of its unique model for sustainable drug development as described in a recent peer-reviewed manuscriptAttruby continues to demonstrate clinical differentiation as a first-choice therapy in ATTR-CM with the greatest TTR stabilization on the market (≥90%) and the most rapid benefit on clinical outcomes observed within 1 month, with 7,804 unique patient prescriptions written by 1,856 unique prescribers as of February 20, 2026PROPEL 3 for oral infigratinib successfully met its primary endpoint (p1,700 unique patients claimed under the dedicated ICD-10 code (E20.810) during the 24-month period from October 2023-2025.The Company initiated CALIBRATE-PEDS, a registrational Phase 2/3 study of encaleret in pediatric ADH1.The Company also plans to initiate RECLAIM-HP, a Phase 3 study of encaleret in chronic hypoparathyroidism in the second half of 2026. Infigratinib – FGFR3 inhibitor: PROPEL 3, the Phase 3 clinical trial of infigratinib in achondroplasia, successfully achieved its pre-specified primary efficacy endpoint of change from baseline in absolute height velocity (AHV) at Week 52 (p

Cytokinetics Reports Fourth Quarter 2025 Financial Results and Provides Business Update

MYQORZO® Approved for Adults with Symptomatic Obstructive HCM in U.S., China and Europe; U.S. Launch Underway with First Prescriptions Dispensed within Days of Drug Availability Supplemental NDA for MAPLE-HCM Submitted to FDA in Q1 2026 Expect to Share Topline Results from ACACIA-HCM in Q2 2026 Company Provides 2026 Financial Guidance;~$1.2 Billion in Cash, Cash Equivalents and Investments as of December 31, 2025 SOUTH SAN FRANCISCO, Calif., Feb. 24, 2026 (GLOBE NEWSWIRE) — Cytokinetics, Incorporated (Nasdaq: CYTK) reported a management update and financial results for the fourth quarter and full year of 2025. The company also provided full year 2026 financial guidance. “The fourth quarter of 2025 marked a defining moment for Cytokinetics with the FDA approval of MYQORZO and our transition into a commercial-stage company,” said Robert I. Blum, Cytokinetics’ President and Chief Executive Officer. “With the U.S. launch of MYQORZO now underway and our first European launch planned in Germany in Q2, we’re entering 2026 with strong momentum. Early prescribing activity and initial customer feedback reinforce that our differentiated label and REMS are resonating with HCPs and patients. We took measures in 2025 to fortify our balance sheet to support our commercial plans and continue with potential label-expanding opportunities in HCM and ongoing clinical trials in heart failure. We are well-positioned to deliver for patients, advance our pipeline, and create long-term value.” Q4 and Recent Highlights Cardiac Muscle Programs MYQORZO™ (aficamten) (cardiac myosin inhibitor) Received approval in December from the U.S. Food and Drug Administration (FDA) for MYQORZO (aficamten) for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) to improve functional capacity and symptoms. Began U.S. commercial launch of MYQORZO in January: Deployed Cardiovascular Account Specialists, who began promotion to healthcare providers (HCPs) in early January.Launched patient and HCP marketing campaigns across promotional channels.Activated online portal for MYQORZO REMS simultaneous with drug availability.Launched MYQORZO & You™ to provide personalized patient support, access and reimbursement assistance and affordability programs for eligible patients. Announced approval from the China National Medical Products Administration (NMPA) for MYQORZO for the treatment of adults with New York Heart Association (NYHA) class II-III oHCM, to improve exercise capacity and symptoms.Received approval from the European Commission (EC) for MYQORZO for the treatment of symptomatic (NYHA class II-III) oHCM in adult patients, following the adoption of a positive opinion recommending marketing authorization in the European Union (EU) by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA).Advanced European commercial readiness activities, including preparing Health Technology Assessment (HTA) dossiers for all key European markets. Expanded launch readiness activities and continued hiring of medical and commercial teams in Germany ahead of expected Q2 2026 launch.The New Drug Submission (NDS) for aficamten was accepted for review by Health Canada.Submitted Supplemental New Drug Application (sNDA) to the FDA for MAPLE-HCM.Advanced the ongoing clinical trials program for aficamten: Continued conduct of ACACIA-HCM, a pivotal Phase 3 clinical trial of aficamten in patients with non-obstructive hypertrophic cardiomyopathy (nHCM). Continued conduct in the Japan cohort of ACACIA-HCM.Completed enrollment of CAMELLIA-HCM, a Phase 3 clinical trial of aficamten in Japanese patients with oHCM. CAMELLIA-HCM is being conducted by Bayer in collaboration with Cytokinetics to support potential marketing authorization in Japan.Continued enrolling patients in CEDAR-HCM, a clinical trial of aficamten in a pediatric population with symptomatic oHCM. Presented additional data from MAPLE-HCM at the Hypertrophic Cardiomyopathy Medical Society Scientific Sessions and American Heart Association Scientific Sessions 2025 expanding on the treatment effect of aficamten vs. metoprolol on patient symptom burden and cardiac biomarkers and showing that significantly more patients on aficamten achieved positive or complete response compared to metoprolol.Published the following manuscripts: “Epidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023” in Journal of the American College of Cardiology: Advances.“Aficamten in Obstructive Hypertrophic Cardiomyopathy: A Multi-Domain, Patient-Level Analysis of the MAPLE-HCM Trial” in Journal of the American College of Cardiology.“Effect of Aficamten vs Metoprolol on Patient-Reported Health Status in Obstructive Hypertrophic Cardiomyopathy” in Journal of the American College of Cardiology.“Effect of Aficamten in Women Compared with Men with Obstructive Hypertrophic Cardiomyopathy in SEQUOIA-HCM” in Circulation: Heart Failure.“Efficacy and Safety of Aficamten in Children and Adolescents with Obstructive Hypertrophic Cardiomyopathy: Study Design and Rationale of CEDAR-HCM” in Circulation: Heart Failure.“Efficacy and Safety of Extended Treatment with Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy in FOREST-HCM” in European Heart Journal.“Longitudinal Analyses of Healthcare Resource Utilization and Costs Among Patients with Obstructive Hypertrophic Cardiomyopathy” in Journal of Medical Economics.“Impact of Cardiovascular Complications on Economic Burden for Patients with Hypertrophic Cardiomyopathy” in Journal of Cardiac Failure – Intersections. omecamtiv mecarbil (cardiac myosin activator) Continued conduct of COMET-HF, a confirmatory Phase 3 clinical trial of omecamtiv mecarbil in patients with symptomatic heart failure with severely reduced ejection fraction. Published the following manuscripts: “Efficacy and Safety of Omecamtiv Mecarbil in Heart Failure with Reduced Ejection Fraction According to Age: the GALACTIC-HF Trial” in Journal of the American College of Cardiology – Heart Failure.“Multiple-Dose Up-Titration Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Omecamtiv Mecarbil in Healthy Chinese Subjects” in Drugs in R&D. ulacamten (cardiac myosin inhibitor) Continued patient enrollment in Cohort 1 of AMBER-HFpEF, a Phase 2 clinical trial of ulacamten in patients with symptomatic heart failure with preserved ejection fraction (HFpEF) with left ventricular ejection fraction (LVEF) ≥ 60%. Pre-Clinical Development and Ongoing Research Continued pre-clinical development and research activities directed to additional muscle biology focused programs. Corporate Supported a three-year initiative led by the American Heart Association to address disparities in access to care, diagnosis, and treatment for people living with HCM. Expected 2026 Corporate Milestones Cardiac Muscle Programs MYQORZO® (aficamten) (cardiac myosin inhibitor) Report topline results from ACACIA-HCM in Q2 2026.Launch MYQORZO in Germany in Q2 2026.Receive potential FDA approval of the sNDA for MAPLE-HCM in Q4 2026.Complete enrollment in the adolescent cohort of CEDAR-HCM in Q4 2026.Receive potential approval from Health Canada in 2H 2026. omecamtiv mecarbil (cardiac myosin activator) Continue patient enrollment in COMET-HF through 2026. ulacamten (cardiac myosin inhibitor) Complete enrollment in Cohort 1 of AMBER-HFpEF in Q1 2026, and complete enrollment in Cohort 2 by the end of 2026. Ongoing research Continue ongoing pre-clinical development and research activities directed to additional muscle biology focused programs Fourth Quarter and Full Year 2025 Financial Results Cash Equivalents and Investments As of December 31, 2025, the company had approximately $1.22 billion in cash, cash equivalents and investments compared to $1.25 billion at September 30, 2025. The 2025 year-end balance includes $100 million in proceeds from the drawing on the Tranche 5 of the Royalty Pharma Multi Tranche Loan. Excluding the proceeds from this loan, cash, cash equivalents and investments would have declined by approximately $134 million during the fourth quarter of 2025. Revenues Total revenues for the fourth quarter of 2025 were $17.8 million compared to $16.9 million for the same period in 2024. Total revenues for the full year of 2025 were $88.0 million compared to $18.5 million in 2024. Total revenues for the full year 2025 benefitted primarily from the successful completion of the technology transfer totaling $52.4 million to Bayer Consumer Care AG, an affiliate of Bayer AG, in the second quarter of 2025 and the recognition of $15.0 million in the fourth quarter of 2025 related to milestones triggered by the approvals of MYQORZO in the United States and China under the Sanofi License Agreement. Research and Development (R&D) Expenses R&D expenses for the fourth quarter of 2025 were $104.4 million, which included $14.2 million of non-cash stock-based compensation expense, compared to $93.6 million for the same period in 2024, which included $12.5 million of non-cash stock-based compensation expense. R&D expenses for the full year of 2025 were $416.0 million, which included $54.5 million of non-cash stock-based compensation compared to $339.4 million in 2024, which included $44.0 million of non-cash stock-based compensation expense. The increase for the full year was primarily due to advancing our clinical trials, higher personnel-related costs including stock-based compensation, and medical affairs activities. General and Administrative (G&A) Expenses G&A expenses for the fourth quarter of 2025 were $91.7 million, which included $16.3 million of non-cash stock-based compensation expense, compared to $62.3 million for the same period in 2024, which included $13.8 million of non-cash stock-based compensation expense. G&A expenses for the full year of 2025 were $284.3 million, which included $57.7 million of non-cash stock-based compensation compared to $215.3 million in 2024, which included $53.8 million of non-cash stock-based compensation expense. The increase for the full year was primarily driven by investments toward commercial readiness including the hiring of our U.S. sales force primarily in the fourth quarter of 2025 and higher non-sales personnel-related costs. Net Income (Loss) Net loss for the fourth quarter of 2025 was $183.0 million, or $(1.50) per share, basic and diluted, compared to a net loss of $150.0 million, or $(1.26) per share, basic and diluted, for the same period in 2024. Net loss for the year of 2025 was $785.0 million, or $(6.54) per share, basic and diluted, compared to a net loss of $589.5 million, or $(5.26) per share, basic and diluted, in 2024. 2026 Financial Guidance The company today announced financial guidance for 2026: GAAP Combined R&D and SG&A Expense*$830 million to $870 millionNon-cash stock-based compensation expense included in GAAP Combined R&D and SG&A Expense$130 million to $120 million *GAAP Combined R&D and SG&A expense does not include 1) collaboration expenses which can include reimbursed expenses and cost of inventory sales of aficamten to partners, 2) potential costs related to commercialization of aficamten in nHCM, and 3) the effect of GAAP adjustments as may be caused by events that occur subsequent to publication of this guidance including, but not limited to, Business Development activities. Conference Call and Webcast Information Members of Cytokinetics’ senior management team will review the company’s fourth quarter 2025 results on a conference call today at 4:30 PM Eastern Time. The conference call will be simultaneously webcast and can be accessed from the Investors & Media section of Cytokinetics’ website at www.cytokinetics.com or directly at the following link: Cytokinetics Q4 2025 Earnings Conference Call. An archived replay of the webcast will be available via Cytokinetics’ website for six months. About Cytokinetics Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. Cytokinetics’ MYQORZO™ (aficamten) is a cardiac myosin inhibitor approved in the U.S., Europe and China for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Aficamten is also being studied for the potential treatment of non-obstructive HCM. Cytokinetics is also developing omecamtiv mecarbil, an investigational cardiac myosin activator for the potential treatment of patients with heart failure with severely reduced ejection fraction and ulacamten, an investigational cardiac myosin inhibitor for the potential treatment of heart failure with preserved ejection fraction, while continuing pre-clinical research and development in muscle biology. For additional information about Cytokinetics, visit www.cytokinetics.com and follow us on X, LinkedIn, Facebook and YouTube. Disclaimer  Omecamtiv mecarbil and ulacamten are investigational medicines. They have not been approved nor determined to be safe or efficacious for any disease state or any indication by FDA or any other regulatory agency. Forward-Looking Statements This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the “Act”). Cytokinetics claims the protection of the Act’s Safe Harbor for forward-looking statements. Examples of such statements include, but not limited to, statements, express or implied, relating to our ability to launch MYQORZO in Germany in 2Q of 2026, our receipt of regulatory approval for our sNDA for MAPLE-HCM in Q4 of 2026, our or our partners’ research and development and commercial readiness activities, including the initiation, conduct, design, enrollment, progress, continuation, completion, timing and results of any of our clinical trials, or more specifically, our ability to complete enrollment of CEDAR-HCM and AMBER-HFpEF by any target date, our ability to complete patient enrollment of COMET-HF by any target date, our ability to announce the results of ACACIA-HCM in of the second quarter of 2026, our ability to announce the results of any of our clinical trials by any particular date, the timing of interactions with FDA or any other regulatory authorities in connection to any of our drug candidates and the outcomes of such interactions; statements relating to the potential patient population who could benefit from aficamten, omecamtiv mecarbil, ulacamten, CK-089 or any of our other drug candidates; statements relating to our ability to receive additional capital or other funding, including, but not limited to, our ability to meet any of the conditions relating to or to otherwise secure additional loan disbursements under any of our agreements with entities affiliated with Royalty Pharma or additional milestone payments from Sanofi or Bayer in connection with our collaborations for aficamten in China or Japan respectively; statements relating to our operating expenses or cash utilization for the remainder of 2025 or any other period, and statements relating to our cash balance at any particular date or the amount of cash runway such cash balances represent at any particular time. Such statements are based on management’s current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to Cytokinetics’ need for additional funding and such additional funding may not be available on acceptable terms, if at all; potential difficulties or delays in the development, testing, regulatory approvals for trial commencement, progression or product sale or manufacturing, or production of Cytokinetics’ drug candidates that could slow or prevent clinical development or product approval; patient enrollment for or conduct of clinical trials may be difficult or delayed; the FDA or foreign regulatory agencies may delay or limit Cytokinetics’ or its partners’ ability to conduct clinical trials; Cytokinetics may incur unanticipated research and development and other costs; standards of care may change, rendering Cytokinetics’ drug candidates obsolete; and competitive products or alternative therapies may be developed by others for the treatment of indications Cytokinetics’ drug candidates and potential drug candidates may target. For further information regarding these and other risks related to Cytokinetics’ business, investors should consult Cytokinetics’ filings with the Securities and Exchange Commission, particularly under the caption “Risk Factors” in Cytokinetics’ Quarterly Report on Form 10-Q for the quarter ended September 30, 2025. Forward-looking statements are not guarantees of future performance, and Cytokinetics’ actual results of operations, financial condition and liquidity, and the development of the industry in which it operates, may differ materially from the forward-looking statements contained in this press release. Any forward-looking statements that Cytokinetics makes in this press release speak only as of the date of this press release. Cytokinetics assumes no obligation to update its forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release. CYTOKINETICS® and the CYTOKINETICS C-shaped logo are registered trademarks of Cytokinetics in the U.S. and certain other countries. MYQORZOTM is a trademark of Cytokinetics in the U.S., and a registered trademark in the European Union. MYQORZO & You TM is a trademark of Cytokinetics in the U.S. Contact:Cytokinetics Diane WeiserSenior Vice President, Corporate Affairs(415) 290-7757  Cytokinetics, IncorporatedCondensed Consolidated Balance Sheets(in thousands)            December 31, 2025 December 31, 2024  (unaudited)   ASSETS     Current assets:    Cash and short-term investments $882,221  $1,076,014 Other current assets  34,754   31,926 Total current assets  916,975   1,107,940 Long-term investments  335,048   145,055 Property and equipment, net  79,194   65,815 Operating lease right-of-use assets  75,979   75,158 Other assets  17,341   7,705 Total assets $1,424,537  $1,401,673  LIABILITIES AND STOCKHOLDERS’ DEFICIT     Current liabilities:    Accounts payable and accrued liabilities $105,615  $75,692 Short-term operating lease liabilities  19,111   18,978 Current portion of convertible and long-term debt  41,181   11,520 Derivative liabilities measured at fair value  31,100   11,300 Deferred revenue  1,612   52,370 Other current liabilities  3,833   9,814 Total current liabilities  202,452   179,674 Term loan, net  246,384   93,227 Convertible notes, net  869,597   552,370 Liabilities related to revenue participation right purchase agreements, net  520,559   462,192 Long-term operating lease liabilities  107,970   112,582 Liabilities related to RPI Transactions measured at fair value  137,200   137,000 Total liabilities  2,084,162   1,537,045 Commitments and contingencies    Stockholders’ deficit    Common stock  123   118 Additional paid-in capital  2,826,341   2,563,876 Accumulated other comprehensive income  630   2,398 Accumulated deficit  (3,486,719)  (2,701,764)Total stockholders’ deficit  (659,625)  (135,372)Total liabilities and stockholders’ deficit $1,424,537  $1,401,673  Cytokinetics, Incorporated Condensed Consolidated Statements of Operations (in thousands except per share data) (unaudited)            Three Months Ended December 31, Years Ended December 31,  2025 2024 2025 2024Revenues:        Collaboration revenues $2,755  $1,927  $8,686  $3,474 License and milestone revenues  15,000   15,000   79,353   15,000 Total revenues  17,755   16,927   88,039   18,474 Operating expenses:        Research and development  104,398   93,629   416,026   339,408 General and administrative  91,723   62,338   284,271   215,314 Total operating expenses  196,121   155,967   700,297   554,722 Operating loss  (178,366)  (139,040)  (612,258)  (536,248)Interest expense  (14,274)  (8,938)  (45,579)  (37,701)Non-cash interest expense on liabilities related to revenue participation right purchase agreements  (16,061)  (13,656)  (58,289)  (48,811)Interest and other income, net  11,470   15,014   48,420   51,534 Change in fair value of derivative liabilities  900   1,200   4,200   1,300 Change in fair value of liabilities related to RPI Transactions  13,300   (4,600)  (200)  (19,600)Debt conversion expense  —   —   (121,249)  — Net loss $(183,031) $(150,020) $(784,955) $(589,526)Net loss per share — basic and diluted $(1.50) $(1.26) $(6.54) $(5.26)Weighted-average shares in net loss per share — basic and diluted  122,434   118,075   120,103   111,979 

Medtronic Receives Reimbursement Approval for Symplicity Spyral™ Renal Denervation System in Japan

Milestone expands patient access to the first and most studied renal denervation therapy for hypertension. DUBLIN – February 19, 2026 – Medtronic plc (NYSE: MDT), a global leader in healthcare technology, today announced that Japan’s Ministry of Health, Labour and Welfare (MHLW) has granted reimbursement approval for the Symplicity Spyral™ renal […]

Cardiac Surgeons at Allegheny General Hospital First in Region to Successfully Perform Transcatheter Tricuspid Valve Replacement Procedure

PITTSBURGH, Feb. 20, 2026 /PRNewswire/ — Cardiac experts from Pittsburgh’s Allegheny Health Network’s (AHN) Allegheny General Hospital (AGH) announced today they are the first in the region and among the first in the state to successfully perform a transcatheter tricuspid valve…