— The EluPro BioEnvelope findings demonstrate the bioactive properties and superior healing response compared to synthetic materials for cardiac implantable electronic devices (CIEDs) — GAITHERSBURG, Md., July 01, 2025 (GLOBE NEWSWIRE) — Elutia Inc. (Nasdaq: ELUT) (“Elutia” or the “Company”), a pioneer in drug-eluting biomatrix technologies, today announced the publication of a new study describing the bioinductive effects of its antibiotic-eluting CIED biologic envelope in the Journal of Functional Biomaterials. Researchers from the Department of Cardiac Sciences at the Cumming School of Medicine found that the biomatrix in EluPro controlled inflammation and supported vascularization, key to a healthy device pocket with less scarring and risk of infection. Formation of a fibrotic capsule and bacterial colonization are known precursors to pocket infection, which can compromise both near-term procedural success and long-term pocket health following CIED implantation. The preclinical study demonstrated that EluPro stimulates early proangiogenic signals and reduced fibrosis over time. “What’s compelling is that we’re seeing not just a signal, but a clear biological effect,” said Dr. Paul W.M. Fedak, a professor and cardiac surgeon-scientist, and Director, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary. “The EluPro BioEnvelope initiates early proangiogenic signaling that promotes vascularization and healthier tissue integration — while simultaneously reducing fibrosis over time. This dual regenerative and protective response represents a meaningful step forward in improving outcomes for patients with implantable cardiac devices.” In mechanistic studies, fibroblasts, cells critical for tissue repair and healing, released significantly higher levels of growth and wound healing factors in the biomatrix environment compared to controls (p
